壳寡糖协同双歧杆菌对荷瘤鼠免疫功能的影响

doi:10.3969/j.issn.1004-616x.2007.06.016

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2007, Vol. 19 ›› Issue (6): 487-490.doi: 10.3969/j.issn.1004-616x.2007.06.016

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Effects of Chitosan Oligosaccharide and Bifidobacteria on Immune Function in Tumor-bearing Mice

GUAN Jie, WU Yan-min, WANG Hui, QIAN Li-li, Li Dian-jun

Department of Immunology, Qiqihaer Medical College, Qiqihaer 161042, China

Received:2007-01-05 Revised:2007-07-10 Online:2007-11-30 Published:2007-11-30
Contact: LI Dian-jun

Abstract

Abstract: BACKGROUND ＆ AIM: Establish the tumor animal model of the H22 liver cancer in mice,and study the inhibition effects of chitosan oligosaccharide and bifidobacteria on the tumor. MATERIALS AND METHODS: Chitosan oligosaccharide and bifidobacteria were injected into tumor-bearing mice,the growth and pathological changes of the tumor were examined;and the immunological functions were measured. RESULTS: Growth of tumor were inhibited by chitosan oligosaccharide and bifidobacteria. They could increase the content of IL-2 and IFN-γ and the weights of spleen and thymus of the mice.Necrosis was observed in the tumor tissue. CONCLUSION: Chitosan oligosaccharide and bifidobacteria could inhibit the growth of tumor,improve immunity and induce tumor necrosis.

Key words: chitosan oligosaccharide, bifidobacteria, tumor, inhibition

CLC Number:

R73-36 ，R392.12

GUAN Jie, WU Yan-min, WANG Hui, QIAN Li-li, Li Dian-jun. Effects of Chitosan Oligosaccharide and Bifidobacteria on Immune Function in Tumor-bearing Mice[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2007, 19(6): 487-490.

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Effects of Chitosan Oligosaccharide and Bifidobacteria on Immune Function in Tumor-bearing Mice

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